PHARMACEUTICAL PACKAGING SEALING PERFORMANCE SOLUTION

Pharmaceutical packaging is an integral part of pharmaceutical products. The main function of drug packaging is to protect the drug, so that it can prevent the damage of biological, chemical and physical external factors during the circulation process of the drug from the factory to the consumer. It can also have the function of maintaining the stable quality of the drug itself. If the drug packaging breaks, leaks and other problems during the circulation process, then the main function of the drug packaging will lose its effect, and the drugs in the package will also have problems such as leakage, moisture, deterioration, etc., which will have many adverse effects on the enterprise.

There are several reasons why the sealing performance of pharmaceutical packaging is not up to standard:

1. The physical and mechanical properties of packaging materials such as composite film bags are not enough. During the circulation process, the packaging bags will break and the hard contents will puncture the packaging bags.
2. The sealing strength of the composite film bag is not enough, mainly due to the unreasonable setting of the heat sealing parameters in the production process. If the temperature is too high, it will easily cause excessive heat sealing such as undercutting, and if the temperature is too low, there will be false sealing. Or the manufacturer itself chooses packaging materials with poor heat sealing performance.
3. The torque of the bottle cap in the bottle packaging is not suitable. If the torque is too small, it will affect the sealing performance of the bottle cap.

The above reasons for poor sealing performance can be monitored by testing instruments such as material mechanical properties/torque. The packaging sealing performance test of the finished product has a corresponding national standard “GB/T 15171 Flexible Packaging Sealing Performance Test Method”. According to the standard requirements, the test sample needs to be placed in a vacuum chamber, immersed in water, and vacuumed to a certain degree of vacuum. Hold for 30 seconds. Observe whether there is cracking of the sample or cracking of the seal, or whether there are continuous air bubbles.

experiment procedure

1. Put the sample into the vacuum chamber, put an appropriate amount of distilled water in the vacuum chamber, and the sample needs to be completely immersed in water.
2. Set the experimental parameters, the vacuum degree is set to -30KPa, the vacuum time is 30 seconds, and the threshold is set to 1KPa.
3. Return to the experiment interface, click the experiment button, the instrument will automatically evacuate to -30KPa, and then keep it for 30 seconds. If the pressure decays during the experiment, it will automatically replenish the pressure with constant pressure.
4. After the experiment is completed, click the green stop button if it is qualified, and click the red stop button if leakage occurs. The instrument will automatically count the qualified rate of test products.